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Binding Kinetics of Complementary Oligonucleotide Sequences using OpenSPR™
Overview Oligonucleotides are an important area of biotechnological and pharmaceutical research, as demonstrated by the recent success of mRNA-based COVID-19 vaccines. Oligonucleotides, namely siRNA a...
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Epitope Characterization of Influenza Targets using OpenSPR™
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated hosts. Hence, annual formulation upd...
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Characterization of Complementary Oligonucleotide Sequences using Alto™
Overview Oligonucleotides offer a promising vector for the treatment of diseases related to gene expression and have recently transformed the vaccine industry with the resounding success of mRNA-based...
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Characterization of Fc Gamma Receptors and IgG Interactions using Alto™: Comparison to BLI
Overview Label-free analysis of biomolecular interactions is critical in the development of biologics, but current analytical instruments are not equipped to meet the needs of the modern biologics res...
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Label-Free Characterization of the Interleukin-6 Receptor and Anti-IL-6R Antibody Drug Tocilizumab using Alto™
Overview Therapeutic monoclonal antibodies are one of the fastest growing classes of drugs, and interleukins and their signal pathways are a preeminent target for treatments due to the vast number of ...
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Label-Free Characterization of ImmTAC® Bispecific Molecules for T-Cell Redirecting Immunotherapy using Alto™
Overview Bispecific proteins offer a promising new modality for the treatment of cancer and have subsequently gained attention in recent years as the next generation of cancer immunotherapy. In this a...
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Characterization of Biomolecular Interactions using Alto™: Comparison to Conventional SPR
Overview Label-free analysis of biomolecular interactions is a critical tool for the development of biologics. Conventional label free analytical instruments require relatively large amounts of sample...
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Kinetic and Epitope Characterization of Influenza Antiviral Targets Using Alto™ Digital Surface Plasmon Resonance
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated hosts. Hence, annual formulation upd...
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Binding of SARS-CoV-2 Antibody to the Spike Protein Receptor Binding Domain Using OpenSPR-XT™
Overview The analysis of binding kinetics with SPR plays a critical role in the understanding of COVID-19. This includes basic research for understanding the viral infection mechanisms, the developmen...
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Binding Kinetics of a Virus-Like Particle using OpenSPR-XT™
Overview Virus-like particles (VLPs) are complex molecules composed of multiple subunits that resemble a specific virus without its genetic material. VLPs are frequently used to study viruses without ...
