Nucleic Acid / Aptamer Interactions

Quantitatively characterize your interaction with binding kinetics & affinity data. 

Protein_Aptamer

Protein-Aptamer

Ligand: Aptamer (biotinylated) immobilized onto Streptavidin Sensor

Analyte: Lysozyme

kon = 1.8×105 M-1s-1

koff = 2.6×10-3 s-1

KD = 14.6 nM

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Outcomes:

  • Determine kon and koff (kinetics) and KD (affinity) values
  • Quantify levels of protein at different development stages
  • Yes/No binding and screening of SELEX aptamers
  • Screening for ligand binding partners
  • Specificity

Use Cases:

  • Aptamer characterization
  • Analyzing DNA and RNA interactions
  • Expressed protein interactions
  • Extracted protein interactions
  • Aptamer quality control
  • Drug discovery
  • Therapeutic and diagnostic applications
  • Aptamer biosensor development

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OpenSPR-Instrument

Overview

OpenSPR is the world’s only benchtop surface plasmon resonance (SPR) instrument. It provides high quality, label-free interaction analysis for a fraction of the cost of existing solutions. Our unique nano-structured sensor surface uses localized SPR (LSPR) to deliver repeatable, highly sensitive kinetic data.

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